The role of Dickkopf-1 as a biomarker in systemic lupus erythematosus and active lupus nephritis

Abstract Background Systemic lupus erythematosus (SLE) is a chronic disease which mainly attributed to autoantibodies, cytokines, and immune complex deposition. Studies have demonstrated that cytokines autoantibodies were strongly associated with renal diseases can be used for the prediction of patients nephritis (LN). However, antibodies dsDNA reduction complements also detected in non-LN as well clinically non-active SLE patients. The current study was performed detect role serum DKK-1 biomarker identification LN its relation activity severity. conducted on fifty diagnosed who according Lupus International Collaborating Clinics (SLICC) classification criteria SLE, addition thirty healthy control volunteers matched age sex. Assessment done using Erythematosus Disease Activity Index (SLEDAI). severity Collaborative Clinics/American College Rheumatology (SLICC/ACR) damage index. Serum levels measured all participants by ELISA commercially available kits. Results significantly higher among active cases compared no controls (9197.60 μg/uL ± 2939.2 vs. 6405.15 2018.91 2790.33 833.49 μg/uL) respectively ( p -values < 0.001). concentration positive negative anti-double-stranded DNA (dsDNA) -value According receiver operating characteristic (ROC) curve analysis, level at statistically significant 98% sensitivity 70% specificity 90% 63% specificity. Conclusion could diagnose high reliable key molecule diagnosis prognostic indicator LN.